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Some attribute the name to a New York City police captain, Alexander S.

There are several explanations of how that neighborhood was named. The Tenderloin took its name from an older neighborhood in New York with similar characteristics. The Ambassador Hotel is a neighborhood renovated single room occupancy building that sits on the eastern edge of the Tenderloin.

The area has among the highest levels of homelessness and crime in the city. Part of the western extent of the Tenderloin, Larkin and Hyde Streets between Turk and O'Farrell, was officially named ' Little Saigon' by the City of San Francisco. The eastern extent, near Union Square, overlaps with the Theater District. The terms 'Tenderloin Heights,' and ' Tendernob' refer to the area around the boundary between the Upper Tenderloin and Lower Nob Hill. It contains the Uptown Tenderloin Historic District. The northern boundary with Lower Nob Hill has historically been set at Geary Street. Encompassing about 50 square blocks, it is historically bounded on the north by Geary Street, on the east by Mason Street, on the south by Market Street and on the west by Van Ness Avenue. The Tenderloin is a neighborhood in downtown San Francisco, in the flatlands on the southern slope of Nob Hill, situated between the Union Square shopping district to the northeast and the Civic Center office district to the southwest.

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